Talk about playing with your food.

Scientists have discovered a poisonous frog that takes up a toxin from its food and makes the chemical even deadlier. It's the first example of a frog using chemistry to make a poison for its own defense stronger.

Several types of frogs from South America, Australia, and Madagascar carry deadly poisons in their skin. When raised in zoos and aquariums, however, most of the frogs grow up to be totally harmless.

About 10 years ago, researchers from the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Md., figured out that many poison dart frogs take up toxins from the food they eat, including ants and other insects. If such prey isn't available, the frogs get no toxins to store in their skins.

More recently, scientists were working with a toxin called pumiliotoxin 251D, often found on the skin of the tropical frog known as the green poison dart frog (Dendrobates auratus). The scientists sprinkled the toxin on termites and fruit flies, which they then fed to captive frogs.

Later analyses of the frogs' skins showed that about 80 percent of the pumiliotoxin 251D had been converted to a different toxin, called allopumiliotoxin 267A. The new toxin was five times more poisonous to mice than the original chemical.

Scientists were surprised by their findings. Any creature that tries to eat a wild Dendrobates would get an even bigger surprise. It's quite possible that its frog-leg dinner would be its last!—E. Sohn